Microneedling in Dermatology: A Review

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Microneedling is a minimally invasive procedure that is becoming a widely utilized Tprocedure. Microneedles (MNs) are needlelike structures with diameters in the size order of microns and lengths ranging from 250 μm to 2,000 μm. In percutaneous collagen induction (PCI) therapy, MNs penetrate the dermis and lead to the reorganization of collagen fibers and release of growth factors that stimulate the formation of new collagen, elastin, and capillaries in the skin (A. Singh & S. Yadav, 2016). Microneedling can also augment transdermal drug delivery through creation of micropores that reaches different levels of the skin depending on needle size.
Microneedling was first explored by Orentreich and Orentreich in 1995, who described “subcision” or dermal needling for the treatment of scars (Orentreich & Orentreich, 1995). In 1997, Camirand and Doucet described needle dermabrasion using a “tattoo pistol” to treat scars (Camirand & Doucet, 1997). Finally in 2006, Fernandes developed the dermaroller for percutaneous collagen induction (PCI) therapy (Fernandes, 2005). Since that time, microneedling has been explored for a wide variety of skin conditions.
This review provides an overview of the current literature regarding the efficacy of microneedling performed for dermatologic conditions. PubMed database was used to search for studies and search terms included “microneedling” and “percutaneous collagen induction.” Priority was given to studies with human subjects and prospective, randomized trials.
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