Various mechanisms eliciting symptoms in GERD and its most common phenotypic presentation, nonerosive reflux disease (NERD), have been suspected and investigated. One study now suggests that superficial nerves in the oesophageal epithelium might have a key role in the pathogenesis of NERD and could represent a potential target for topical therapies.
Refers to Woodland, P. et al. Superficial esophageal mucosal afferent nerves may contribute to reflux hypersensitivity in non-erosive reflux disease. Gastroenterologyhttp://dx.doi.org/10.1053/j.gastro.2017.07.017 (2017)