Charcot–Marie–Tooth Disease type 1A (CMT1A) is caused by a duplication of the peripheral myelin protein gene 22 at chromosome 17p11.2-12. There is limited data regarding whether body mass index (BMI) affects electrophysiological or clinical data in those with CMT1A.Methods:
Electrophysiological data, the Charcot–Marie–Tooth examination score (CMTES) and BMI from 101 patients with known CMT1A were obtained and analyzed.Results:
When controlling for age, a higher BMI does not affect ulnar motor nerve conduction studies in those with CMT1A, but rather components of the CMTES (loss of pinprick and motor strength in the lower extremities).Conclusions:
BMI and clinical components of the CMTES are correlated, but it is uncertain which came first—whether the loss of lower extremity pinprick sensation and motor strength results in a higher BMI or if higher BMI results in these signs.