Reduction of non-enzymatic antioxidants in plasma during ECMO-treatment in ARDS by influence A H1N1

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Abstract

Purpose:

In critically ill patient it is observed a severe oxidative stress, not only due to the acute pathology but also for some therapeutic treatments. The aim of the present study was to analyze the variations of non-enzymatic antioxidants in plasma during veno-venous ECMO-treatment in a homogeneous population of critical patients with ARDS.

Materials and methods:

We carried out a retrospective study enrolling all patients with ARDS by influence A H1N1 treated with veno-venous ECMO. In all patients included, we have recorded clinical and laboratory parameters considered indicators of oxidative stress during the first week of treatment.

Results:

With regard to non-enzymatic antioxidants evaluated, we observed that both albumin and uric acid decreased significantly, at all observation times, after ECMO-treatment [(25.88 ± 4.51, 18.05 ± 4.27, 16.32 ± 4.57, 19.07 ± 5.10, p < 0.05)(g/l), (5.46 ± 1.43, 2.30 ± 1.15, 2.90 ± 2.09, 2.07 ± 1.03, p < 0.05)(mg/dl), respectively]. At the same time the amount of insulin administered daily was increased with statistical significance (p = 0.03).

Conclusions:

The veno-venous ECMO-treatment causes a significant reduction of some of the major non-enzymatic antioxidants and a possible increase in insulin resistance in patients with ARDS by influence A H1N1.

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