Zinc–L-Carnosine Complex (Polaprezinc) for the Treatment of Binge Eating: Three Case Reports

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To the Editors
Zinc (Zn) plays an important part in appetite regulation.1 Zinc deficiency has been documented in patients with anorexia nervosa or bulimia nervosa.2 However, the relationship between Zn deficiency and binge-eating disorder (BED) has not been reported. L-Carnosine (CAR) is an endogenous dipeptide comprising β-alanine and L-histidine. The latter is a precursor of histamine. The central histaminergic system has been implicated in the regulation of feeding behavior.3 L-Carnosine has also been found to inhibit food intake in chickens.4 Polaprezinc (PLZ) is a Zn-CAR complex prescribed for the treatment of gastric ulcers in Japan. A daily dose of 150 mg of PLZ contains 34 mg of Zn and 116 mg of CAR. We describe 3 patients with BED according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, or subthreshold BED (binge eating [BE] of insufficient frequency to satisfy Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria) who experienced considerable relief from BE behavior and comorbid impulsive symptoms with addition of PLZ to ongoing antidepressant treatment.
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