Comparison of T lymphocyte subsets in aplastic anemia and hypoplastic myelodysplastic syndromes

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Abstract

Aims:

This study aims to compare the proportion of peripheral blood T lymphocyte subsets and related blood cell and bone marrow cytology indexes between patients with aplastic anemia (AA) and hypoplastic myelodysplastic syndrome (hypo-MDS), and investigate the clinical identification significance.

Materials and methods:

A total of 41 patients with AA and 46 patients with hypo-MDS were collected, and the proportions of peripheral blood T lymphocyte subsets, CD3− CD16/CD56+ NK cells, CD3+ CD57+ T-LGL cells and CD19+ B lymphocytes were detected by flow cytometry.

Key findings:

The CD4+/CD8+ ratio decreased in the AA and hypo-MDS groups, and the difference was statistically significant when compared with that in the control group (P < 0.05). However, there was no significant difference between AA and hypo-MDS groups (P > 0.05). The proportions of CD3− CD16/CD56+ NK cells and CD3+ CD57+ T-LGL cells in the hypo-MDS group were distinctly higher than those in the AA group (P < 0.05). However, the proportion of CD19+ B lymphocyte was obviously lower than that in the AA group (P < 0.05). Furthermore, the proportions of reticulocytes, bone marrow progenitor cells and immature red blood cells in the hypo-MDS group were significantly more than those in the AA group (P < 0.05), and the proportion of mature lymphocytes in the hypo-MDS group was distinctly lower than that in the AA group (P < 0.05).

Significance:

Changes of T lymphocyte subsets and the proportions of large granular lymphocytes and B lymphocytes can be utilized as indexes in the differential diagnosis between AA and hypo-MDS.

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