The relationship of plasma decoy receptor 3 and coronary collateral circulation in patients with coronary artery disease

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Abstract

Objective:

Previously, decoy receptor 3 (DcR3) was found to be a potential angiogenetic factor, while the relationship of DcR3 with coronary collateral circulation formation has not been investigated. In this study, we aimed to investigate whether plasma decoy receptor 3 levels was associated with CCC formation and evaluate its predictive power for CCC status in patients with coronary artery disease.

Methods:

Among patients who underwent coronary angiography with coronary artery disease and had a stenosis of ≥ 90% were included in our study. Collateral degree was graded according to Rentrope Cohen classification. Patients with grade 2 or 3 collateral degree were enrolled in good CCC group and patients with grade 0 or 1 collateral degree were enrolled in poor CCC group.

Results:

Plasma DcR3 level was significantly higher in good CCC group (328.00 ± 230.82 vs 194.84 ± 130.63 ng/l, p < 0.01) and positively correlated with Rentrope grade (p < 0.01). In addition, plasma DcR3 was also positively correlated with VEGF-A. Both ROC (receiver operating characteristic curve) and multinomial logistical regression analysis showed that plasma DcR3 displayed potent predictive power for CCC status.

Conclusions:

Higher plasma DcR3 level was related to better CCC formation and displayed potent predictive power for CCC status.

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