Myelosuppression, Bone Disease, and Acute Renal Failure: Evidence-based recommendations for oncologic emergencies

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Oncologic emergencies associated with multiple myeloma include myelosuppression (anemia, neutropenia, and thrombocytopenia), bone-related emergencies, and acute renal failure.


This article reviews the pathophysiology of these multiple myeloma-associated oncology emergencies and provides a framework for assessment and effective intervention.


A comprehensive review of the levels of evidence, focusing on assessment, diagnosis, comorbidities, treatment, ongoing monitoring, and patient education, are presented to support the plan of care for at-risk patients.


Attention to signs and symptoms is the foundation for preventing these emergencies or managing additional escalation of symptoms.

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