Restless legs syndrome and cerebrovascular/cardiovascular events: Systematic review and meta‐analysis

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Accumulating literature evidence suggests for an increased risk for both cerebrovascular and cardiovascular events in patients with restless legs syndrome (RLS)1 highlighting sympathetic hyperactivity in RLS as a potential mediator for this association.4
The aim of the present systematic review and meta‐analysis was to evaluate the association of RLS with cerebrovascular/cardiovascular outcomes using data from available observational studies evaluating the association of RLS with acute ischaemic stroke (AIS) or myocardial infarction (MI).
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