Treatment of grey zone lymphoma using the R-CODOX-M/R-IVAC protocol: Two case reports

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We report our experience with 2 patients diagnosed with grey zone lymphoma (GZL). The histopathological characteristics of lymphomatous tissues in these patients ranged between those of diffuse large B-cell lymphoma (DLBCL) and the classical Hodgkin lymphoma.

Patient concerns:

A 52-year-old female presented to the hospital with a history of lower abdominal pain of metastatic origin for 2 days. She was diagnosed with acute appendicitis and had undergone emergency surgery. A 17-year-old male was admitted to the hospital because of acute left upper abdomen pain.


Both patients are diagnosed of GZL primarily based on histopathology.


Both patients were treated with R-CODOX-M/R-IVAC regimen for 4 to 6 cycles.


The short-term curative effect was complete response; no recurrence was observed as of 32-month follow-up.


R-CODOX-M/IVAC regimen exhibited relatively good curative effect. International Prognostic Index score and lactate dehydrogenase level may correlate with prognosis of these patients.

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