MWASTools: an R/bioconductor package for metabolome-wide association studies

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Abstract

Summary

MWASTools is an R package designed to provide an integrated pipeline to analyse metabonomic data in large-scale epidemiological studies. Key functionalities of our package include: quality control analysis; metabolome-wide association analysis using various models (partial correlations, generalized linear models); visualization of statistical outcomes; metabolite assignment using statistical total correlation spectroscopy (STOCSY); and biological interpretation of metabolome-wide association studies results.

Availability and implementation

The MWASTools R package is implemented in R (version > =3.4) and is available from Bioconductor: https://bioconductor.org/packages/MWASTools/.

Contact

m.dumas@imperial.ac.uk

Supplementary information

Supplementary data are available at Bioinformatics online.

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