Early‐life sensitization to hen's egg predicts asthma and rhinoconjunctivitis at 14 years of age
Atopic diseases are among the most common chronic diseases in children and adolescents representing a substantial health and socioeconomic burden. Sensitization has been shown to precede the development of atopic disease,1 and early sensitization to both inhalant and food allergens has in some studies been shown to increase the risk for the development of asthma 1 and rhinoconjunctivitis 7 later in childhood. The association between IgE sensitization and allergic diseases has been studied intensively, but only few studies have addressed the role of both transient and persistent early‐life sensitization to specific allergens 1 for later development of allergic diseases finding persistent sensitization to food allergens important. This indicates that early‐life sensitization might be a predictor for later development of allergic airway diseases.
The prospective design of The Danish Allergy Research Center (DARC) cohort with frequent clinical follow‐ups including measurements of specific IgE offers a unique opportunity to investigate the role of early sensitization to specific allergens. The aim of this study was to explore the association between transient and persistent sensitization to groups of allergens as well as individual allergens in early life and the development of asthma and rhinoconjunctivitis at 6 and 14 years of age.