Low-Dose Exposure to Ionizing Radiation Deregulates the Brain-Specific miR-134 in Interventional Cardiologists

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Abstract

In recent years, there has been a growing concern about the health risks for contemporary interventional cardiologists who have a high and unprecedented levels of occupational ionizing radiation (IR) exposure.1

microRNAs (miRNAs), a class of short and highly conserved non-coding RNA molecules (~22 nucleotides), have been shown to become dysregulated in many human diseases.2

The stability and tissue specificity of circulating miRNAs make them ideal biomarkers to explore the molecular mechanisms underlying the association between chronic low-dose radiation exposure and potential disease risk. The purpose of this study was to apply a miRNome-wide microarray to characterize the plasma miRNA profiles in interventional cardiologists professionally exposed to IR.

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