Electroconvulsive Therapy as an Intervention for Autoimmune Neuropsychiatric Disease

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To the Editor:
Autoimmune neuropsychiatric disease is a poorly understood phenomenon with a sparse body of literature, and much of the research has focused on neuropsychiatric systemic lupus erythematosus (NPSLE). Electroconvulsive therapy (ECT) may be effective in treatment of refractory cases of NPSLE by stimulating the immune and neurotrophic systems.1 Electroconvulsive therapy increases levels of brain-derived neurotrophic factor (BDNF),2 and animal models show that BDNF induces neurogenesis and has antidepressant effects.1 The following case demonstrates the successful use of ECT to treat refractory autoimmune neuropsychiatric disease.
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