Biomarkers for Prostate Biopsy and Risk Stratification of Patients with Newly Diagnosed Prostate Cancer

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Abstract

Introduction:

Many new markers are now available as an aid for decisions about prostate biopsy for men without prostate cancer and/or to improve risk stratification for men with newly diagnosed prostate cancer.

Methods:

A literature review was performed on currently available markers for use in decisions about prostate biopsy and initial prostate cancer treatment.

Results:

Although total prostate specific antigen cutoffs were traditionally used for biopsy decisions, prostate specific antigen elevations are not specific. Repeating the prostate specific antigen test, and adjusting for factors like age, prostate volume and changes over time can increase specificity for biopsy decisions. The Prostate Health Index and 4Kscore® are new prostate specific antigen based markers that can be offered as second line tests to decide on initial or repeat prostate biopsy. The PCA3 urine test and ConfirmMDx tissue test are additional options for repeat biopsy decisions. For men with newly diagnosed prostate cancer genomic tests are available to refine risk classification and may influence treatment decisions.

Conclusions:

Numerous secondary testing options are now available that can be offered to patients deciding whether to undergo prostate biopsy and to those with newly diagnosed prostate cancer.

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