Maternal Use of Antiepileptic Agents During Pregnancy and Major Congenital Malformations in Children

    loading  Checking for direct PDF access through Ovid

Abstract

Clinical Question

Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children?

Bottom Line

Certain antiepileptic drugs were associated with increased rates of congenital malformations (eg, spina bifida, cardiac anomalies). Lamotrigine (2.31% in 4195 pregnancies) and levetiracetam (1.77% in 817 pregnancies) were associated with the lowest risk and valproate was associated with the highest risk (10.93% in 2565 pregnancies) compared with the offspring of women without epilepsy (2.51% in 2154 pregnancies).

Related Topics

    loading  Loading Related Articles