Limiting cardiovascular events associated with HIV and antiretroviral therapy
A number of studies have documented an association between HIV infection, ART, and CVD . There is a 1.5 to two-fold increase in the risk of myocardial infarction (MI) associated with HIV that persists in individuals who are virally suppressed on ART [2,3]. The Data Collection on Adverse Events of Anti-HIV drugs have documented an increased risk of MI associated with the cumulative use of protease inhibitors and abacavir exposure [4,5]. In a heterogeneous cohort of HIV-positive persons, the Data Collection on Adverse Events of Anti-HIV drug study showed that the cumulative use of darunavir, but not atazanavir, was independently associated with gradually increasing CVD risk following 7 years .
Dolutegravir, an unboosted integrase strand transfer inhibitor, is a preferred drug option in first-line drug regimens based on its improved efficacy, tolerability, dosing, and high genetic barrier to resistance [7,8]. In clinical trials, regimens containing dolutegravir showed superiority to efavirenz at 144 weeks (SINGLE) or ritonavir-boosted darunavir (FLAMINGO), as well as noninferiority to raltegravir (SPRING-2) [9–11]. Moreover, dolutegravir demonstrated more improved lipid profiles than that observed with efavirenz or boosted darunavir, regardless of the choice of two-drug nucleoside analogue regimen backbones .
Dolutegravir may be a treatment option of choice for an aging population with risk factors for CVD. The STRIIVING trial found switching to dolutegravir/abacavir/lamivudine noninferior to maintaining a stable suppressive regimen . Against this background, the current issue of AIDS presents the important findings from the NEAT022 randomized clinical trial designed to assess the clinical impact of switching from a protease inhibitor to a dolutegravir regimen in a HIV-infected population at high risk for CVD. Selection criteria included participants who were 50 years of age or older or participants with Framington scores of greater than 10%, defined as having a more than 10% likelihood for MI, angina, or a serious coronary event in the next 10 years. As in other recent switch trials, any patients with prior virologic failures or documented resistance mutations were excluded from the study.
The trial followed 415 participants who were virally suppressed on a protease inhibitor-based regimen for at least 6 months (median 5 years) and were randomized to either maintain their current protease inhibitor regimen or replace their protease inhibitor component for dolutegravir retaining their two-drug nucleoside backbone. After 48 weeks, 93.1% of the persons in the dolutegravir group and 95.2% in the protease inhibitor group remained virally suppressed, establishing noninferiority of switching to dolutegravir.
At 48 weeks, there were significant improvements in lipid profiles in the dolutegravir arm of the study. There were significant reductions from baseline in total cholesterol, (−8.7%) non-high-density lipoprotein (HDL) cholesterol (−11.3%), low-density lipoprotein cholesterol (−7.7%), and triglyceride (−18.4%) in the dolutegravir group as compared to slight elevations from baseline in the protease inhibitor group. Overall, the total cholesterol-to-HDL ratio fell by 7% in the dolutegravir and rose by 0.4% in the protease group. Serious adverse effects in both arms did not significantly differ.
This is the first switch trial targeting a population with moderate to high cardiovascular risk. With longer life expectancy, patients over 50 years of age represent a growing share of the HIV population. In United States, 12% of the new HIV diagnosis were aged 50–59, and 5% were aged 60 and over in 2015 .