Improving the Reproducibility and Quality of Reporting for Animal Studies in Inflammatory Bowel Disease
Mouse models of inflammatory bowel disease have greatly contributed to our current understanding of inflammatory bowel disease pathogenic mechanisms and provide useful controlled systems for evaluating the preclinical therapeutic potential or “proof of concept” of novel immunomodulatory or biological therapies. A large number of well-characterized models of intestinal inflammation are available to researchers,1 each with its own specific advantages and limitations, based on the research question under investigation. The intestinal inflammatory phenotypes that develop in these animal models are generated through a variety of techniques (i.e., chemical induction, targeted genetic manipulation, congenics, spontaneous generation, etc.).