Prognostic role of C-reactive protein in patients with nasopharyngeal carcinoma: A meta-analysis and literature review

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C-reactive protein (CRP) has been shown to be associated with several tumors. However, its association with nasopharyngeal carcinoma (NPC) is not well characterized. We performed a literature review and meta-analysis to assess the prognostic relevance of elevated CRP levels in patients with NPC.


A literature search for relevant studies was performed on PubMed (Medline), the Cochrane Library, and Web of Science databases. Hazard ratios (95% confidence intervals) were calculated to assess the association between elevated CRP levels and survival outcomes.


Five studies with a combined study population of 5215 patients with NPC were included. Pooled hazard ratios for overall survival and distant metastasis-free survival were 1.84 (95% CI = 1.57–2.17) and 1.81 (95% CI = 1.53–2.14), respectively. Subgroup analyses showed that types of indicators and treatment before inclusion had no significant impact on the observed association.


Elevated serum CRP levels in patients with NPC were associated with worse prognosis.

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