Case report: middle-aged woman from Ghana with unsteady gait and enlarging cerebellar mass
Neurosarcoidosis (NS) is an uncommon manifestation of systemic sarcoidosis, with a propensity for middle-agedwomen. Often discovered only at autopsy, rates of neurologic involvement (5%–10%) reported in the literature underscore a lack of sensitivity and specificity in current diagnostic methods.Patient concerns:
Herein, we describe a 53-year-old woman who presented with gait imbalance and distal extremity muscular weakness. She was known to harbor a brain mass (4 years in duration) that was monitored and recently seemed to enlarge.Diagnosis:
A subsequent brain biopsy showed necrotizing granulomatous inflammation suggestive of NS. However, no clinical or radiologic evidence of activity was found in other organs.Interventions and outcomes:
Ultimately, endo and transbronchial biopsies were performed, providing histologic confirmation of systemic sarcoidosis.Lessons:
This approach is advised in all instances of suspected NS where systemic involvement is in question.