New onset of myasthenia gravis after intravesical Bacillus Calmette-Guerin: A case report and literature review

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Abstract

Rationale:

Recently, drug-related myasthenia gravis (MG) has received attention, because the number of reported cases involving MG associated with immune checkpoint inhibitors, a new immunotherapy, is increasing. We present a case involving the new onset of MG, in which the symptoms started shortly after intravesical Bacillus Calmette-Guerin (BCG) for bladder cancer.

Patient concerns:

A 69-year-old male with bladder cancer developed ptosis and diplopia 4 days after the completion of a treatment regimen with intravesical BCG weekly for 6 weeks.

Diagnoses:

Ocular MG was confirmed by a positive serum anti-acetylcholine receptor antibody test.

Interventions:

Treatment with high-dose methylprednisolone pulse therapy was given, after insufficient treatment with pyridostigmine bromide and 10 mg/d prednisolone.

Outcomes:

Symptoms resolved completely 12 days after high-dose methylprednisolone pulse therapy.

Lessons:

Intravesical BCG could be listed as a novel drug that may induce a new onset of MG along with drugs such as D-penicillamine and immune checkpoint inhibitors.

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