Role of the combination of FA and T2* parameters as a new diagnostic method in therapeutic evaluation of parkinson's disease

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Abstract

Background

Simple diffusion delivery (SDD) has attained good effects with only tiny amounts of drugs. Fractional anisotropy (FA) and relaxation time T2* that indicate the integrity of fiber tracts and iron concentration within brain tissue were used to evaluate the therapeutic effect of SDD.

Purpose

To evaluate therapeutic effect of SDD in the Parkinson's disease (PD) rat model with FA and T2* parameters.

Study Type

Prospective case–control animal study.

Population

Thirty-two male Sprague Dawley rats (eight normal, eight PD, eight SDD, and eight subcutaneous injection rats).

Field Strength/Sequence

Single-shot spin echo echo-planar imaging and fast low-angle shot T2WI sequences at 3.0T.

Assessment

Parameters of FA and T2* on the treated side of the substantia nigra were measured to evaluate the therapeutic effect of SDD in a PD rat model.

Statistical Tests

The effects of time on FA and T2* values were analyzed by repeated measurement tests. A one-way analysis of variance was conducted, followed by individual comparisons of the mean FA and T2* values at different timepoints.

Results

The FA values on the treated side of the substantia nigra in the SDD treatment group and subcutaneous injection treatment group were significantly higher at week 1 and lower at week 6 than that of the PD control group (SDD vs. PD, week 1, adjusted P = 0.012; subcutaneous vs. PD, week 1, adjusted P < 0.001; SDD vs. PD, week 6, adjusted P = 0.004; subcutaneous vs. PD, week 6, adjusted P = 0.024). The T2* parameter in the SDD treatment group and subcutaneous injection treatment group was significantly higher than that in the PD control group at week 6 (SDD vs. PD, adjusted P = 0.032; subcutaneous vs. PD, adjusted P < 0.001).

Data Conclusion

The combination of FA and T2* parameters can potentially serve as a new effective evaluation method of the therapeutic effect of SDD.

Data Conclusion

Level of Evidence: 1

Data Conclusion

Technical Efficacy: Stage 4

Data Conclusion

J. Magn. Reson. Imaging 2017.

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