Plasma Leptin and Premenstrual Syndrome: A Review

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Premenstrual syndrome (PMS) is characterized by physical and psychological symptoms in the luteal phase. Leptin can influence PMS as it acts on the hypothalamic-pituitary-gonadal axis.


The aim of this study was to evaluate data in the literature about the profile of plasma leptin in women with PMS.

Evidence Acquisition

We performed a search of databases using both descriptors. Three studies were identified. They included 181 participants. Two of these studies found higher leptin levels in women with PMS.


Conflicting results were found regarding the leptin levels in the luteal phase and the correlation between leptin, estradiol, and progesterone levels.

Conclusions and Relevance

Leptin could have a role in the pathophysiology of PMS and indicate degree of severity of PMS. Future studies on the role of leptin in PMS are needed.

Target Audience

Obstetricians and gynecologists, family physicians.

Learning Objectives

After completing this activity, the learner should be better able to describe the correlation between women with PMS and leptin concentration, analyze if there is a difference between leptin concentration in the phases of the menstrual cycle, and foresee the future clinical applicability of leptin's concentration in women with PMS.

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