In 2017, the American Psychological Association (APA) celebrates the 125th anniversary of its founding. This special issue commemorates this milestone by providing long- and short-term views on the history of APA and its role in psychology in America. The opening paper presents an overview of initiatives and challenges facing the field of psychology and APA in five periods, each roughly 25 years in length. The remaining eight articles review specific issues and areas of activity over varying lengths of time in more recent years. Issues of policy involvement, relations with the media, and involvement with the courts are described, as well as developments related to social justice, education, science, practice, and publications.