Rotavirus Genotypes Circulating in Brazil Before and After the National Rotavirus Vaccine Program: A Review

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Abstract

Background:

Rotavirus vaccines created the opportunity to control diarrhea in children. We describe the rotavirus genotypes before and after the rotavirus vaccine introduction in Brazil.

Methods:

We reviewed the distribution of rotavirus genotypes in Brazil before and after vaccine introduction by searching publication.

Results:

Eighty-six studies reported 6884 (15.2%) rotavirus episodes among 45,305 children. Rotavirus caused 22.4% and 11.6% of cases before and after vaccine introduction. G1P[8], G9P[8] and G2P[4] heterotypic strains were most common before and after vaccine introduction.

Conclusions:

The vaccines may have selected heterotypic strains in this highly vaccinated population.

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