Sugammadex and Oral Contraceptives: Is It Time for a Revision of the Anesthesia Informed Consent?
Interestingly, a similar potential risk exists with the administration of common perioperative antibiotics. The package insert for a common oral contraceptive ORTHO-NOVUM tablets (norethindrone/ethinyl estradiol) states, “Contraceptive effectiveness may be reduced when hormonal contraceptives are coadministered with antibiotics, anticonvulsants, and other drugs that increase the metabolism of contraceptive steroids.” While some of the implicated medications include antibiotics that are frequently administered in the perioperative period, there has been a previous lack of discussion and counseling regarding those potential risks. Although studies have not been definitively conclusive, many antibiotics are believed to decrease oral contraceptive efficacy, including cephalosporins, tetracyclines, antifungals, penicillins, macrolides, metronidazole, and sulphonamides.1 Particular individuals have shown more susceptibility to fluctuating plasma hormonal levels in the face of antibiotic administration.2 Some antibiotics cause interruption of the enterohepatic cycling of ethinylestradiol, leading to inhibition of hydrolysis of the conjugated hormone with subsequent increased fecal loss and ultimately lower circulating levels of ethinylestradiol. Others promote induction of cytochrome P450 hepatic microsomal enzymes, increasing metabolism of both the estrogen and progesterone component. We find it interesting that a new product such as sugammadex with only in vitro-binding studies warrants such attention and change in practice, but previous warning of interactions between oral contraceptives and antibiotics has to this date been relatively dismissed.
Perhaps we need more definitive data to support changing our system. Or perhaps a revision of the anesthetic consent should contain a general statement such as, “You may receive medications during your anesthetic that could interfere with the effectiveness of oral contraceptives. If you are using oral contraceptives, consider alternative methods of birth control for 7 days following your anesthetic.” This disclosure would cover potential interactions with sugammadex, antibiotics, and other medications.