Ace Gene Plays A Key Role In Reducing Blood Pressure In Hypertensive Elderlies After Resistance Training Resistance Exercise And Ace Polymorphism

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Abstract

Hypertension is a difficult disease to control and exercise training plays a key role in hypertension control. Some individuals are not responsive to exercise training, so we highlight the polymorphism of angiotensin I converting enzyme, as a factor responsible for this lack of responsiveness. The aim of this study was to evaluate the influence of ACE (I/D) genotypes on effects of resistance training on blood pressure and chronic inflammation. Eighty-six hypertensive volunteers, aged between 60 and 80, were evaluated. They performed 16 weeks of resistance training at 50% of 1 maximal repetition. The greatest benefits were seen on homozygous of the Insertion allele, whom presented reduction of systolic blood pressure (SBP: 129.31±13.34 vs. 122.56±9.68 mmHg, p<0.001) and diastolic blood pressure (DBP: 79.18±8.05 vs. 70.12±7.71 mmHg, p<0.01) during daytime period, and in 24h period (SBP: 127.12±13.65 vs. 121.06±9.68 mmHg, p<0.001 and DBP: 71.87±8.39 vs. 68.75±8.72 mmHg, p<0.05) and also increased circulating adiponectin levels (4.04±1.79 vs. 6.00±2.81 ng/mL, p<0.01). Other genotypes showed no changes in blood pressure and biochemical parameters. Our results suggest a cardio protective factor of I allele, since only those homozygous showed reductions in blood pressure and increases in adiponectin.

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