Targets and Receptor of Sexual Transmission of Zika Virus

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To the Editor:
The publication on “Cellular targets and receptor of sexual transmission of Zika virus” is very interesting.1 Bagasra et al1 concluded that “only certain subclass of immunoglobulin (Ig)G (ie, IgG4) can cross the blood-Sertoli barrier therefore, a successful vaccine must provoke a subclass of IgG can quell ZIKV inside the seminiferous tubules.” Indeed, this observation might also be explained by the nanostructure of the Ig. The size of Ig is an important factor to determine its ability to cross membranes that may be related to several diseases, including sexually transmitted infections, such as HIV infection2 and hepatitis.3 IgG4 has the smallest size compared with IgG1, IgG2, and IgG3. The IgG4 molecule also proved to have the highest ability to cross the selective membrane of placenta.
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