Periosteal Ewing Sarcoma in a 65-Year-Old Man: A Case Report

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Ewing sarcoma is predominantly a pediatric bone malignancy involving the medullary canal. Periosteal Ewing sarcoma, a subtype arising from the periosteum, is exceedingly rare, with approximately 30 reported cases in the literature. We describe a case of periosteal Ewing sarcoma in the tibia of a 65-year-old man. Magnetic resonance imaging revealed a heterogeneous mass in the proximal tibial diaphysis without medullary involvement. The diagnosis was confirmed histologically after biopsy. The patient was treated with neoadjuvant chemotherapy, radical resection, and adjuvant chemotherapy.


To the best of our knowledge, this case report describes the oldest documented patient with periosteal Ewing sarcoma.

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