Global Pulmonary Vascular Remodeling in Pulmonary Hypertension Associated with Heart Failure and Preserved or Reduced Ejection Fraction
We hypothesized that pulmonary venous hypertension in heart failure (HF) leads to predominate remodeling of pulmonary veins and that the severity of venous remodeling is associated with the severity of pulmonary hypertension (PH) in HF.Methods—
Patients with HF (n=108; 53 preserved and 55 reduced ejection fraction) with PH (HF-PH; pulmonary artery systolic pressure (PASP) ≥ 40 mmHg) were compared to normal Controls (n=12) and patients with primary pulmonary veno-occlusive disease (PVOD; n=17). In lung specimens from autopsy (Control, HF-PH and 7 PVOD) or surgery (10 PVOD), quantitative histomorphometry was performed in all analyzable arteries (n=4,949), veins (n=7,630) and small indeterminate vessels (IV, n=2,168) to define % medial thickness (%MT) [arteries] and % intimal thickness (%IT) [arteries, veins and IV] relative to external diameter.Results—
The average arterial %MT (Control 6.9; HF-PH 11.0; PVOD 15.0); arterial %IT (Control 4.9; HF-PH 14.9; PVOD 31.1); venous %IT (Control 14.0; HF-PH 24.9; PVOD 43.9) and IV %IT (Control 10.6; HF-PH 25.8; PVOD 50.0) in HF-PH were higher than Controls (p<0.0001 for all) but lower than PVOD (p≤0.005 for all). PASP (mmHg) was lower in HF-PH (median 59 [IQR 50-70]) than PVOD (91 [82-103]). PASP correlated with arterial %MT (r=0.41) and arterial %IT (r=0.35) but more strongly with venous %IT (r=0.49) and IV %IT (r=0.55) (p<0.0001 for all). Associations between PASP and venous or IV %IT remained significant after adjusting for arterial %MT and %IT and did not vary by HF type. In patients with right heart catheterization (30 HF-PH; 14 PVOD) similar associations between the transpulmonary gradient and pulmonary vascular remodeling existed, with numerically stronger associations for venous and IV %IT. While the PASP was slightly higher in HF-PH patients with right ventricular dysfunction, pulmonary vascular remodeling was not more severe. Pulmonary vascular remodeling severity was associated with reductions in the diffusing capacity of the lungs.Conclusions—
In HF, PH is associated with global pulmonary vascular remodeling but the severity of PH correlates most strongly with venous and small IV intimal thickening, similar to the pattern observed in PVOD. These findings expand our understanding of the pathobiology of PH in HF.