Relationship between smoking and total antioxidant status, total oxidant status, oxidative stress index, vit C, vit E.

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Tobacco smoking contains many toxic, carcinogenic and mutagenic chemicals, as well as stable and unstable free radicals. In this study, we aimed to assess the vitamin E, vitamin C and total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in smoking and non-smoking men.


This case-control analytical study was conducted on 78 smoking and 82 non-smoking men. Fagerström nicotine-dependence test was used to assess the participants' addiction status. Low-density lipoprotein-c, high-density lipoprotein-c, total cholesterol, triglyceride, fasting blood glucose, vitamin E, vitamin C, TAS and TOS levels were determined.


The mean age of 160 men who participated in our study was 33.0 ± 10.6 years. The comparison of smoker and non-smoker groups was made in terms of the parameters of TAS, TOS, OSI, vitamin C and vitamin E; it was seen that TAS (P = .003), vitamin C (P < .001) and vitamin E (P < .001) values in non-smokers' group were found significantly higher than smokers. In non-smokers, vitamin C level was 4.3 times more than the smokers. In non-smokers, vitamin E level was 6.9 times more than the smokers. The values of TOS (P < .001) and OSI (P < .001) in smokers were significantly higher than the control group.


The parameters of TAS, vitamin C and vitamin E were significantly higher in the non-smoker group than in the smoker group. The levels of TOS and OSI were higher in the smoker group. It is known that cigarette smoking leads to various diseases because of the free radicals it contains.

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