Article Summaries for January 2018 Psychosomatic Medicine, Volume 80, Issue 1
Slavich and Shields provide a detailed description of the recently developed Stress and Adversity Inventory (STRAIN), an online system for systematically assessing lifetime stress exposure. They summarize evidence for reliability and validity of the STRAIN and the relevance of the STRAIN to biobehavioral processes. The STRAIN demonstrated good usability and acceptability; good concurrent, discriminant, and predictive validity; and excellent test-retest reliability over 2 to 4 weeks.
Oxidative DNA damage is associated with atherosclerosis, cardiovascular disease, cancer, and diabetes. Shimanoe et al. examined whether urinary 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative DNA damage, was associated with perceived stress or depressive symptoms. Results showed that higher perceived stress was significantly associated with higher 8-OHdG, whereas no association was observed between depressive symptoms and 8-OHdG. Increased oxidative DNA damage may therefore play a role in the adverse risk of psychosocial stress for various diseases.
Wu et al. investigated whether prenatal stress exposure and methylation in inflammation-related genes were associated with childhood adiposity in a Mexican birth cohort. A stress index was created based on four prenatally administered stress-related factors (exposure to violence, crisis in family systems, anxiety, and depression). Contrary to the authors’ hypothesis, prenatal stress was found to be associated with decreased childhood adiposity, while cord blood IL6 methylation was found to be associated with increased childhood adiposity.
Wolf et al. examined trauma exposure and posttraumatic stress disorder (PTSD) in association with cellular aging among 339 veterans. Using an index of cellular age derived from DNA methylation data, they found that PTSD hyperarousal symptoms were associated with accelerated cellular age relative to chronological age. Moreover, accelerated cellular age also predicted mortality.
Murdock et al. examined whether perceived health risk and depressive symptoms before a disaster were associated with post-disaster inflammation markers (CRP, IL6, and TNF-R1). Participants were part of a stress and health study whose baseline visits had occurred before a major petrochemical explosion nearby. Results revealed no main effect of the disaster on inflammation markers but showed an interaction between pre-disaster depressive symptoms with perceived health risk as related to post-disaster circulating inflammation markers.
Posttraumatic stress disorder (PTSD) is associated with incident cardiovascular disease (CVD), but little is known about cardiovascular consequences of PTSD in daily life. Edmondson et al. found that PTSD was associated with higher ambulatory systolic blood pressure in working adults, which was partly accounted for by greater anxiety throughout the day and greater systolic blood pressure reactivity to periods of anxiety during the day.
The experience of pain is influenced by psychosocial factors such as stress, socioeconomic status, and low levels of social support. To provide a new animal model for social modulation of pain, Osako et al. examined pain behaviors in the socially monogamous prairie vole experiencing partner loss. In males with a previously established social bond preference for specific partners, separation from the female partner led to hyperalgesia and anxiety-related behaviors; this did not occur in males who did not have a social bond preference.
Despite recognition of the health benefits of exercise, adherence to physical activity (PA) regimens is poor.