Evaluation of Subclinical Atherosclerosis by Ultrasound Radiofrequency Data Technology in Patients With Familial Mediterranean Fever

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The aim of this study was to noninvasively demonstrate the presence of early risk associated with subclinical inflammatory activity in patients with familial Mediterranean fever (FMF) who had stable disease, using ultrasound (US) radiofrequency data technology.


A total of 110 participants, including 55 patients with FMF and 55 healthy control participants, were evaluated with Doppler US. The intima-media thickness and arterial stiffness were measured from bilateral common carotid arteries (CCAs) by the radiofrequency method.


No statistically significant difference was found between the patients with FMF and controls in terms of the right and left CCA intima-media thickness, distensibility coefficient, compliance coefficient, α and β stiffness indices, and pulsed wave velocity (P > .05). Symptom duration and diagnosis and treatment time of the patients with FMF had a negative correlation with the distensibility and compliance measurements obtained by Doppler US (r = –0.324 and –0.303), and a positive (r = 0.380 and 0.339) and statistically significant relationship was detected between the α stiffness index, β stiffness index, and pulsed wave velocity (P < .05).


Common carotid artery intima-media thickness and arterial stiffness measurements can aid in early prediction of cardiovascular disease development in patients with FMF. Radiofrequency data technology provides a noninvasive method for accurately and quantitatively showing the CCA intima-media thickness elevation and the decrease in vascular elasticity in patients with FMF.

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