Human trafficking is a global, multibillion-dollar industry. Most victims are female and more than half are children. At-risk youth continue to attend school with school nurses on the frontline of this health crisis. Using the Peace and Power Conceptual Model, a mixed-methods study was conducted to explore school nurses' awareness, attitudes, and role perceptions in the prevention of commercial sexual exploitation of children. Six peace-power versus power-over power themes and 4 subthemes were identified: “exposure/knowledge, “collaboration,” “role boundaries,” and “creating respite space.” Policy efforts should focus on improving practice conditions for school nurses to support the prevention of commercial sexual exploitation of children.