Prevalence of Anti-tissue Transglutaminase (tTG) Antibodies and Celiac Disease in Children with IBD

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Abstract

Introduction:

Celiac disease can occur in children with Inflammatory bowel disease (IBD) and poses a diagnostic challenge. We evaluated the presence of anti-tissue transglutaminase (tTG) antibodies and celiac disease among children with IBD.

Methods:

In a retrospective chart review, we assessed the prevalence of tTG antibodies and celiac disease and compared with a control group of children with gastrointestinal symptoms without IBD.

Results:

Study population included 130 children with IBD and 257 in the control group. Abnormal tTG levels were found in 6 and 20 patients, respectively (4.6% vs. 7.8%, p = 0.24). One patient with IBD and 12 in the control group had celiac disease (0.8% vs. 4.7%, p = 0.07).

Conclusion:

False positive tTG can occur in children with IBD. The prevalence of celiac disease is not increased in children with IBD compared with non-IBD children with gastrointestinal symptoms and is similar to that in the general population.

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