Giant Porokeratosis With Malignant Transformation to Squamous Cell Carcinoma

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Porokeratosis is a disorder of epidermal keratinization. Clinically these lesions are notable for a raised rim of scale, and histologically they feature the pathognomonic finding of a coronoid lamella. Many variants of porokeratosis exist, and some have demonstrated an increased risk of malignant transformation.1 Immunosuppression has been identified as 1 predisposing factor for the development of porokeratosis.2 Patients with the history of renal transplantation also have an elevated incidence of porokeratosis.
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