Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Pathological Methods and Prognostic Factors in Vestibular Schwannomas

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Abstract

TARGET POPULATION

Adults diagnosed with vestibular schwannomas.

QUESTION 1

What is the prognostic significance of Antoni A vs B histologic patterns in vestibular schwannomas?

RECOMMENDATION

No recommendations can be made due to a lack of adequate data.

QUESTION 2

What is the prognostic significance of mitotic figures seen in vestibular schwannoma specimens?

RECOMMENDATION

No recommendations can be made due to a lack of adequate data.

QUESTION 3

Are there other light microscopic features that predict clinical behavior of vestibular schwannomas?

RECOMMENDATION

No recommendations can be made due to a lack of adequate data.

QUESTION 4

Does the KI-67 labeling index predict clinical behavior of vestibular schwannomas?

RECOMMENDATION

No recommendations can be made due to a lack of adequate data.

QUESTION 5

Does the proliferating cell nuclear antigen labeling index predict clinical behavior of vestibular schwannomas?

RECOMMENDATION

No recommendations can be made due to a lack of adequate data.

QUESTION 6

Does degree of vascular endothelial growth factor expression predict clinical behavior of vestibular schwannomas?

RECOMMENDATION

No recommendations can be made due to a lack of adequate data.

RECOMMENDATION

The full guideline can be found at: https://www.cns.org/guidelines/guidelines-management-patients-vestibular-schwannoma/chapter_6.

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