Azygos vein aneurysm is a rare disease. Surgical resection is usually performed when it ruptures. To avoid the thromboembolism, procedures that do not touch or push the aneurysm are recommended. Herein, we report a case of idiopathic azygos vein aneurysm. A 56-year-old woman was admitted to the hospital for right lateral chest pain. Chest enhanced multi-detector CT revealed an azygos vein aneurysm in the posterior mediastinal space. No thrombus in the aneurysm was detected before surgery. Video-assisted thoracic surgery was performed to treat the aneurysm. The patient was discharged from the hospital 4 days after surgery. Video-assisted thoracic surgery was a good option to treat an azygos vein aneurysm, and an enhanced multi-detector CT was useful for performing surgery safely.