The Efficacy of Transcranical Direct Current Stimulation in Pregabalin Abuse: A Case Report

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To the Editor:
Recently, pregabalin is increasingly being reported as possessing a potential for misuse, and its use is increasing in psychiatric populations. Pregabalin is considered an “ideal psychotropic drug” for recreational purposes to achieve specific desirable effects: alcohol/GHB/benzodiazepine-like effects mixed with euphoria, entactogenic feelings, dissociation, and control opiate/opioid withdrawal. Furthermore, after abrupt or rapid discontinuation of pregabalin insomnia, nausea, headache, or diarrhea have been reported, which may be suggestive of physical dependence.1,2
On the other hand, preliminary results have shown a possible role of the transcranical direct current stimulation (tDCS) for the treatment of substances use disorders (SUDs), especially through the stimulation of dorsolateral prefrontal cortex (DLPFC).3,4
Therefore, considering the psychoactive effects of pregabalin and the absence of care protocols and guidelines for the treatment of pregabalin abuse, tDCS might have the potential and safety profile to be considered as a suitable experimental therapeutic option.
We describe what is possibly the first report of tDCS use as therapy for pregabalin misuse.
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