Numerous psychometric measurements are used to assess for mental health problems in Native American and Alaskan Native (AI/AN) populations; however, few studies have been carried out to assess their validity and reliability within these populations. This study was designed to assess the validity and reliability of numerous measures among the Northern Plains Indians. This article is a partial report, focused on the psychometric measures directed at detecting depression, namely the Beck Depression Inventory (BDI) II, the Center for Epidemiologic Studies Depression (CES-D) Scale, the Tri-Ethnic Depression Scale (TEDS), the Beck Hopelessness Scale (BHS), the Beck Anxiety Inventory (BAI), and the Symptom Checklist-90-Revised (SCL-90–R). Results revealed moderate to strong correlation across all measures, alpha coefficients that exceeded published alphas for the general population, and overall indicated their validity and reliability of these measures, and a 2-factor solution for the BDI-II. While there were limitations to the study, analysis of the results supports the use of each measure with the Northern Plains Indians (NPI) subpopulation, that the NPI subpopulation scored similar to the general population.