A Tale of Two Solutions: High vs Low-Chloride Intravenous Fluids

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While normal saline remains the most commonly utilized intravenous fluid in medicine and has long been a traditional choice, the delivery of solutions with supraphysiologic concentrations of chloride has consistently been associated with a hyperchloremic acidosis. In experimental studies, high-chloride intravenous fluids have been associated with worsened outcomes, while clinical trials have had mixed results for similar end points. In this infographic, we review the composition of commonly utilized low- and high-chloride intravenous fluids as well as summarize the associated studied outcomes.
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