Identification and Management: Sinusoidal obstruction syndrome/veno-occlusive disease related to hematopoietic stem cell transplantation

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Sinusoidal obstruction syndrome (SOS), also called hepatic veno-occlusive disease (VOD), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT) that affects about 1 in 7 patients undergoing this procedure. SOS/VOD is caused by the conditioning regimens administered prior to HSCT; in some cases, SOS/VOD results from chemotherapy alone. SOS/VOD usually develops within three weeks following HSCT; however, it can have later onset.


Clearly understanding how SOS/VOD develops may support prompt detection and treatment when the condition arises.


Research on identification and management of SOS/VOD is summarized, and data from clinical trials are reviewed.


This article describes the syndrome, risk factors, signs and symptoms, and appropriate supportive care and treatment. The authors also offer some practical tips for detecting SOS/VOD and providing patient care, as well as the latest information on treating and preventing this condition.

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