Stem cell modeling of lipid genetics

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Abstract

Purpose of review

To summarize recent advances with respect to the use of human pluripotent stem cells to study the genetics of blood lipid traits.

Recent findings

Human pluripotent stem cell models have been used to elucidate the mechanisms by which genes contribute to dyslipidemia, to discover new lipid-related DNA variants and genes, and to perform drug screens.

Summary

In addition to enabling a better understanding of the genetic basis of lipid metabolism, human pluripotent stem cells are identifying potential therapeutic targets as well as potential therapies.

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