Anisocytosis and leukocytosis are independently related to survival after transcatheter aortic valve replacement
Transcatheter aortic valve replacement (TAVR) has recently emerged as an alternative to surgical aortic valve replacement in patients with severe aortic stenosis and elevated surgical risk.1,2 Despite low short-term mortality and durable valve function, many patients experience adverse events and death at intermediate and late time points. Two-year mortality remains high (17–40%)3,4 in this treated population, presumably due to the burden of cardiovascular and noncardiovascular comorbidities.5 Traditional surgical risk scores for patients with aortic stenosis provide only modest risk discrimination when applied to TAVR.6 Thus, improved methods to identify individuals who remain at high risk after TAVR are needed.
Leukocytosis is a common clinical marker of an individual's response to injury. The distribution of red blood cell size has been shown to reflect bone marrow responsiveness and chronic inflammation.7 Thus, we sought to determine whether baseline and early postprocedural perturbations in blood cell indices are associated with survival after TAVR.