American Journal of Clinical Oncology. 25(1):45-47, FEB 2002

PMID: 11823695

Issn Print: 0277-3732

Publication Date: 2002/02/01


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Phase II Trial of Pyrazoloacridine in Recurrent Platinum-Resistant Ovarian Cancer: A Gynecologic Oncology Group Study

Steven Plaxe;John Blessing;Mark Morgan;John Carlson;

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Abstract

The Gynecologic Oncology Group performed a Phase II study to determine the response rate of pyrazoloacridine (PZA) in patients with platinum-resistant ovarian cancer. PZA was administered at a dose of 750 mg/m2 intravenously over 3 hours every 3 weeks. Among 24 evaluable patients, there was 1 (4.2%) complete and 1 (4.2%) partial response. The major toxicities were hematologic. With the dose and schedule used, PZA had only modest activity in this population.

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