Information de reference pour ce titreAccession Number: | 00000372-200502000-00006.
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Author: | Kazakov, Dmitry V MD, PhD *; Soukup, Roman MD +; Mukensnabl, Petr MD *; Boudova, Ludmila MD, PhD *; Michal, Michal MD *
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Institution: | From *Sikl's Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic and +Private Surgical Practice, Pisek, Czech Republic.
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Title: | |
Source: | American Journal of Dermatopathology. 27(1):27-33, February 2005.
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Abstract: | Brooke-Spiegler syndrome is an autosomal dominantly inherited disease with predisposition to cutaneous adnexal neoplasms, most commonly cylindromas and trichoepitheliomas. We report a patient in whom 11 lesions were removed from the scalp and face for various reasons over a period of 3 years. The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly. The histopathological spectrum in our patient included cylindromas, spiradenomas, trichoepitheliomas, small nodular trichoblastomas, and lymphadenomas. Many lesions had hybrid features of two or more neoplasms. By far the most common composite tumor was spiradenocylindroma. Some spiradenocylindromas demonstrated prominent sebaceous or trichoblastomatous differentiation or both. We suggest the terms "sebaceous spiradenocylindroma" and "trichospiradenocylindroma" for these lesions. The occurrence of sebaceous and trichoblastic differentiation in spiradenocylindromas is a further proof that spiradenoma and cylindroma are not eccrine tumors but neoplasms of the folliculosebaceousapocrine unit.
(C) 2005 Lippincott Williams & Wilkins, Inc.
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Author Keywords: | Brooke-Spiegler syndrome; trichoepithelioma; cylindroma; spiradenoma; spiradenocylindroma; lymphadenoma; trichoblastoma; trichospiradenocylindroma; sebaceous differentiation.
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Language: | English.
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Document Type: | Extraordinary Case Report.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0193-1091
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NLM Journal Code: | 35v, 7911005
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