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Patient monitoring devices supporting wireless transmission can facilitate transport and ambulation of patients in hospitals. To replace wired sensors with wireless sensors, the accuracy and resistance to interference of the wireless sensors have to be documented. We compared the performance of a wireless arterial blood pressure biomedical sensor prototype with standard wired sensors in a clinical setting. Four patients undergoing laparoscopic abdominal surgery were recruited for testing of the device. Lines to a wireless arterial blood pressure sensor and standard wired sensor were connected to the same arterial cannula inserted in the right radial artery. Data from both systems were logged for postprocedure statistical comparison. During the procedure, 13 other electric devices were used, either continuously or intermittently. A sample-by-sample comparison was performed for both wired and wireless data. Statistical tests showed mean difference of 0.71, standard deviation of 0.14, and confidence interval of –1.28 to 1.56), indicating no significant electromagnetic interference on invasive arterial blood pressure monitoring caused by biomedical devices used during surgery. The wireless pressure biomedical sensor with Bluetooth wireless transmission of signals did not interfere with biomedical devices used in the operating room or vice versa.