Influence of Serum and Tissue Micronutrient Levels on the Regression of Untreated Cervical Intraepithelial Neoplasia 2 and 3

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Objective.To determine the influence of micronutrient levels on the regression of untreated cervical intraepithelial neoplasia (CIN).Materials and Methods.Serum and vaginal washings were analyzed for micronutrient levels at the time of diagnosis and after 6 months of observation. Serum and vaginal levels of β-carotene, vitamin E, and retinol were correlated with spontaneous regression, persistence, or progression of CIN. Regression was defined as resolution of the lesion by 2 or more grades (CIN 2 to normal and CIN 3 to CIN 1 or normal). Wilcoxon signed rank, Wilcoxon rank sum, and Spearman correlation were used for data analysis.Results.The overall regression rate was 52% (48/93), including 58% (22/38) of CIN 2 and 47% (26/55) of CIN 3 lesions. The median baseline serum levels for β-carotene, vitamin E, and retinol among those whose lesions regressed were 161 ng/mL, 10,554 ng/mL, and 446 ng/mL, respectively, whereas levels among patients with persistence or progression were 128 ng/mL, 10,286 ng/mL, and 503 ng/mL, respectively. These differences were not statistically significant. The median serum level of β-carotene at 6 months among patients whose lesions regressed was 456 ng/mL compared with 956 ng/mL among the patients with progression or persistence (p = .38). Vaginal levels of β-carotene correlated with serum levels; however, they were also not predictive of CIN regression.Conclusion.Micronutrient levels are not predictive of CIN regression.

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