Chondroid Syringoma With Tyrosine Crystals: Case Report and Review of the Literature.
Constantinescu, Monica B MD; Chan, Jessica B MD; Cassarino, David S MD, PhD
[Report] American Journal of Dermatopathology. 32(2):171-174, April 2010.

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Chondroid syringoma (CS) is a relatively rare cutaneous mixed tumor arising from sweat glands. It usually presents in the head and neck area as an asymptomatic, slow-growing, firm, circumscribed, lobulated nodule within the dermis or subcutaneous fat. CSs share morphologic similarities with their salivary gland counterparts, pleomorphic adenomas (benign mixed tumors). Although the presence of tyrosine-rich crystalloids in mixed tumors of the salivary gland is well recognized, to our knowledge, this finding has not been previously described in mixed tumors of the skin. We report a case of tyrosine crystalline structures in a CS and review the pertinent literature.

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