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Previous clinical studies have investigated cryolipolysis for noninvasive reduction of fat in abdomens, outer thighs, flanks, and backs. This study investigated feasibility of cryolipolysis for inner thigh treatment.This pilot study evaluated a cryolipolysis flat cup vacuum applicator for treatment of inner thigh fat.A prototype vacuum applicator was used to treat n = 11 subjects in a single-side inner thigh study. Cryolipolysis treatment was delivered to the larger thigh while the contralateral thigh served as a control. Follow-ups were conducted at 8 and 16 weeks. Equalization treatments were subsequently delivered to the contralateral thigh. Safety was assessed by monitoring side effects and adverse events. Efficacy was evaluated by ultrasound imaging, clinical photography, and patient surveys.Side effects were typical and resolved spontaneously. Efficacy was demonstrated with ultrasound measurements showing 83% of subjects attained some level of fat layer reduction. Normalized mean reduction in fat layer thickness was 20%, corresponding to 3.3 mm. Patient surveys revealed 91% were satisfied and 82% felt inner thigh cryolipolysis was comfortable. Clinical photographs revealed visible reduction in inner thigh contour after treatment.This study demonstrates feasibility of safe and efficacious cryolipolysis treatment to the inner thigh.